Informatics Publishing Limited

Neeraj Vyawahare ¹, Virendra Kagathara ¹, Rohini Pujari ¹, Manoj Patil ¹, Imtiyaz Ansari ¹, Amol Bhandare ¹

Affiliations
1 AISSMS College of Pharmacy, Kennedy Road, Nr. RTO, Pune-411001, Maharashtra, IN

Abstract

Treatment with selective serotonin reuptake inhibitors (SSRI's) has been shown to cause reduced libido in women. A large body of evidence suggests that serotonin may influence sexual behavior in estradiol + progesterone primed, ovariectomized female rats. In the present study, the effect of 2 weeks of fluoxetine administration (10 mg/kg daily) and coadministration of fluoxetine (same dose) and hydroalcoholic extract of Chlorophytum borivilianum (CB) (100, 300 and 500 mg/kg daily) on copulatory behavior in hormone primed ovariectomized rats was investigated. Fluoxetine significantly reduced various proceptive and receptive behaviors of female rats as compared to normal rats. In contrast, these behavioral parameters were significantly increased by co administration of various doses of CB with fluoxetine as compared to fluoxetine treated rats. The results point towards the potential role and probable use of CB in females with antidepressant induced reduced libido.

Keywords

Chlorophytum borivilianum, Fluoxetine, Libido, Ovariectomized, Proceptive, Receptive.

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Audumbar Mali ¹, Ankush Hake ², Manoj Patil ², Ritesh Bathe ¹, Ashpak Tamboli ³

Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN

Abstract

Two simple, precise, economical, fast and reliable UV methods have been developed for the simultaneous estimation of Paracetamol and Domperidone in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 248 nm and 286 nm for Paracetamol and Domperidone respectively. Method B is area under curve (AUC), in the wavelength range of 220-274 nm for Paracetamol and 262-304 nm for Domperidone. Linearity for detector response was observed in the concentration range of 5-25 μg/ml for Paracetamol and 5-25 μg/ml for Domperidone. The accuracy of the methods was assessed by recovery studies and was found to be 100.11 % and 102.04 % for Paracetamol and 99.10 % and 100.52 % Domperidone by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Paracetamol and Domperidone in commercial pharmaceutical dosage form.

Keywords

Paracetamol, Domperidone, Simultaneous Estimation, Area under Curve, Precision, Absorbance Maxima Method.

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Rajesh Dontham ¹, Sushant Yelpale ¹, Varsha Lokare ¹, Pralhad Gavali ¹, Manoj Patil ¹, Savita Patil ¹

Affiliations
1 Department of Information Technology, Rajarambapu Institute of Technology, Sakharale-Village, Walwa-Taluk, Sangli-District, Maharashtra-State-415 414, IN

Abstract

This paper shares the best practices adapted in the department of Information Technology to enhance the employability of students. Student's placement is considered to be the most important factor for any program in the engineering education. The vision, mission, goals and curriculum of the Information Technology program are designed in-line to prepare the students to be industry ready. Also, the curriculum delivery and evaluation of students are designed and executed with a goal to prepare students to be industry ready. Though all the collaborative efforts of the work force of the IT department and its associates are taken to execute their tasks that should lead to placement of all eligible students, the placement statistics of the department is not satisfactory. The collaboration amongst the work force and its associates must be redefined to improve the placements of the students. To address the student's placements to its best, a team of volunteers from the faculty is formed under best practices activity of Quality Circle at RIT and proposed a solution by defining innovative practices that lead to the betterment of student's placement and titled as "Faculty's Portfolio Collaboration: To enhance Student's placement through faculty's coordination". The practices defined were practiced for one academic year and the results are analyzed. The analysis of the results showed that there is an improvement in the performance of students in most aspects and requires additional efforts for betterment of few other aspects. Necessary measures were also identified and suggested to faculties for the improvement in the portfolios that under performed. The practices defined will be continued in the department to achieve consistency in the results and analyze the same.

Keywords

Portfolios, Collaboration, Placements.

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Santosh Rahangadale ¹, Babu Lal Jangir ¹, Manoj Patil ², Trupti Verma ², Arun Bhandarkar ¹, Prashant Sonkusale ¹, Nitin Kurkure ¹

Affiliations
1 Department of Veterinary Pathology, Maharashtra Animal and Fishery Sciences University, Nagpur, Maharashtra, IN
2 Department of Animal Reproduction, Nagpur Veterinary College, Maharashtra Animal and Fishery Sciences University, Nagpur, Maharashtra, IN

Abstract

Male wistar rats (weighting 160–180 g) were divided in six groups of 6 animals per group. Group A and F served as control. Groups B, C, D and E received acrylamide at 20 mg/kg body weight for 28 days and groups C and E received additionally vitamin E (50 IU/kg body weight) for 1 to 28 days and 29 – 42^nd days of experiment, respectively. The animals from groups A, B, and C were sacrificed on day 28th of experiment and from groups D, E, and F on 42^nd day of experiment, respectively. There was significant decrease in the total sperm count and significant increase in the dead sperm count on day 28^th of study due to acrylamide toxicity. At recovery period, there was significant increase in the total sperm count of vitamin-E-treated group of animals as compared to untreated toxicated rats. But, values were significantly lower than control animals. Microscopically, the lesions in the testes of acrylamide intoxicated rats at 28^th day revealed destruction of seminiferous tubules at periphery. No spermatid and spermatocytes were seen in the seminiferous tubules. Detachment of spermatogonial cells started at periphery of seminiferous tubules. Atrophy of seminiferous tubules was a constant finding. Some tubules showed vacuolar degenerative changes in germinal epithelium. During the recovery period, destruction of seminiferous tubules, detachment of spermatogonial cells, and atrophy of seminiferous tubules were observed in group D and E. Few sections revealed only spermatogonial cells. At recovery period vitamin-E-treated rats revealed somewhat better architecture of the seminiferous tubules. Late spermatids were seen in few seminiferous tubules and other revealed starting of spermatogenesis. Thus, it appears that Vitamin E is not able to protect testes from acrylamide toxicity during active feeding, but after cessation of acrylamide feeding treatment with vitamin E revealed faster recovery as compare to not treated group.

Keywords

Acrylamide toxicity, protective effect of vitamin E, testicular toxicity

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